Antisecretory factor effectively and safely stops childhood diarrhoea: a placebo‐controlled, randomised study

Antisecretory factor counteracts secretory diarrhoea of endocrine origin.

BACKGROUND Dietary induction of antisecretory factor (AF) can reduce diarrhoea in patients with inflammatory bowel disease. Patients with neuroendocrine tumours may suffer from diarrhoea with a prominent secretory component. We studied if AF-therapy could affect this type of diarrhoea. METHODS Six patients with the midgut carcinoid syndrome and two with metastasizing medullary thyroid carcino...

Childhood Pneumonia and Diarrhoea

Epirubicin-Complexed Polypeptide Micelle Effectively and Safely Treats Hepatocellular Carcinoma

Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related mortality worldwide. Epirubicin (EPI) once acted as a main agent for HCC chemotherapy. However, the dosage-dependent side effects seriously limit its application in clinic. The purpose of this study is to develop an effective nanocarrier to improve the efficacy and overcome the limitations of EPI. In this regard, the EP...

Global burden of childhood pneumonia and diarrhoea.

Diarrhoea and pneumonia are the leading infectious causes of childhood morbidity and mortality. We comprehensively reviewed the epidemiology of childhood diarrhoea and pneumonia in 2010-11 to inform the planning of integrated control programmes for both illnesses. We estimated that, in 2010, there were 1·731 billion episodes of diarrhoea (36 million of which progressed to severe episodes) and 1...

Introduction and Classification of Childhood Diarrhoea

1.1 Diarrhoea is a global problem Diarrhoea is one of the most common causes of morbidity and mortality in children worldwide. The word diarrhoea is derived from the Greek "diarrhoia", meaning to flow through. In clinical terms, diarrhoea refers to either an increased stool frequency or a decreased stool consistency, typically a watery quality. The World Health Organization (WHO) defines a case...